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Derailed is a 2005 crime thriller film based on the novel of the same name by James Siegel. The film is directed by Mikael Håfström and stars Clive Owen, Jennifer Aniston, Vincent Cassel, Giancarlo Esposito, David Morrissey, RZA and Xzibit. This was also the first film to be released by The Weinstein Company in the United States. The film is set in Chicago.